Concepts of change propagation analysis in engineering design

Interest in change propagation analysis for engineering design has increased rapidly since the topic gained prominence in the late 1990s. Although there are now many approaches and models, there is a smaller number of underlying key concepts. This article contributes a literature review and organising framework that summarises and relates these key concepts. Approaches that have been taken to address each key concept are collected and discussed. A visual analysis of the literature is presented to uncover some trends and gaps. The article thereby provides a thematic analysis of state-of-the-art in design change propagation analysis, and highlights opportunities for further work

On the accretion mode of the intermediate polar V1025 Centauri

The long white-dwarf spin periods in the magnetic cataclysmic variables EX Hya and V1025 Cen imply that if the systems possess accretion discs then they cannot be in equilibrium. It has been suggested that instead they are discless accretors in which the spin-up torques resulting from accretion are balanced by the ejection of part of the accretion flow back towards the secondary. We present phase-resolved spectroscopy of V1025 Cen aimed at deducing the nature of the accretion flow, and compare this with simulations of a discless accretor. We find that both the conventional disc-fed model and the discless-accretor model have strengths and weaknesses, and that further work is needed before we can decide which applies to V1025 Cen.Comment: 9 pages, 8 figures, To appear in MNRAS, includes low-res figures to reduce siz

Feedback systems in the design and development process

Feedback is essential in the design and development process, occurring in the generation of new designs, in the adaptation of development projects to emerging information, and in coordination and collaboration of project participants—among many other aspects. Feedback also contributes to development project complexity and may cause resistance to desirable changes. But despite the importance of feedback in the design and development process (DDP), relatively few publications have examined this topic in an integrated way. This article makes two contributions towards addressing the gap. First, a conceptual framework is developed to organise perspectives on feedback in the DDP literature. The framework shows how feedback occurs at different levels of the design and development process and how it affects important DDP behaviours, namely goal-seeking, learning and emergence. Second, a system-theoretic model of feedback situations in the design and development process is introduced to synthesise key ideas. We provide concrete examples to show how this new model can be used to frame DDP situations and draw out feedback-related insight

Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data.

IntroductionDeficits in visual perception are well-established in schizophrenia and are linked to abnormal activity in the lateral occipital complex (LOC). Related deficits may exist in bipolar disorder. LOC contains neurons tuned to object features. It is unknown whether neural tuning in LOC or other visual areas is abnormal in patients, contributing to abnormal perception during visual tasks. This study used multivariate pattern analysis (MVPA) to investigate perceptual tuning for objects in schizophrenia and bipolar disorder.MethodsFifty schizophrenia participants, 51 bipolar disorder participants, and 47 matched healthy controls completed five functional magnetic resonance imaging (fMRI) runs of a perceptual task in which they viewed pictures of four different objects and an outdoor scene. We performed classification analyses designed to assess the distinctiveness of activity corresponding to perception of each stimulus in LOC (a functionally localized region of interest). We also performed similar classification analyses throughout the brain using a searchlight technique. We compared classification accuracy and patterns of classification errors across groups.ResultsStimulus classification accuracy was significantly above chance in all groups in LOC and throughout visual cortex. Classification errors were mostly within-category confusions (e.g., misclassifying one chair as another chair). There were no group differences in classification accuracy or patterns of confusion.ConclusionsThe results show for the first time MVPA can be used successfully to classify individual perceptual stimuli in schizophrenia and bipolar disorder. However, the results do not provide evidence of abnormal neural tuning in schizophrenia and bipolar disorder

Dibutyryl Cyclic AMP Modulates Keratinocyte Migration Without Alteration on Integrin Expression

Cyclic adenosine monophosphate (cAMP) has long been regarded as a second messenger and a regulator of human keratinocyte proliferation. It has been demonstrated that cAMP inhibits keratinocyte proliferation when used at high concentrations. Nevertheless, new recent reports have demonstrated that cAMP may stimulate or inhibit keratinocyte growth depending upon the concentration used. Studies to examine the influence of cAMP upon the migration of other cell types have been contradictory. To determine the direct effect of dibutyryl cAMP (DBcAMP) upon human keratinocyte migration, we used a quantitative locomotion assay using a wide range of DBcAMP concentrations. We found a bi-phasic effect of DBcAMP on keratinocyte migration across connective tissue matrices. Keratinocyte locomotion on the matrices was promoted at 10-5 M and 10-6 M of DBcAMP, but not at higher or lower concentrations. Timecourse experiments demonstrated that the effect of DBcAMP on keratinocyte locomotion and proliferation occurred independently. Fluorescence-activated cell sorter analysis demonstrated that the effect of DBcAMP on the migration of human keratinocytes was independent from the modulation of integrin receptors. Although the cellular mechanisms by which DBcAMP promotes keratinocyte migration is unclear, the addition of DBcAMP or TPA to keratinocyte cultures enhanced the synthesis of a 92-kDa metalloproteinase in association with enhanced cellular migration. These observations suggest a possible link between metalloproteinase expression and cellular migration

Encapsulated nanowires : boosting electronic transport in carbon nanotubes

The electrical conductivity of metallic carbon nanotubes (CNTs) quickly saturates with respect to bias voltage due to scattering from a large population of optical phonons. The decay of these dominant scatterers in pristine CNTs is too slow to offset an increased generation rate at high voltage bias. We demonstrate from first principles that encapsulation of one-dimensional atomic chains within a single-walled CNT can enhance the decay of “hot” phonons by providing additional channels for thermalization. Pacification of the phonon population growth reduces the electrical resistivity of metallic CNTs by 51% for an example system with encapsulated beryllium

Ryegrass Seeding Rate Alters Plant Morphology and Size--Possible Implications for Pasture Persistence

Poor persistence of perennial ryegrass (Lolium perenne L.) is a major dairy industry issue in New Zealand and Australia. New ryegrass seed is often drilled at 18-30 kg/ha, although previous research indicated that pastures drilled at 10-12 kg/ha can be just as productive (Frame and Boyd 1986; Praat et al. 1996). High seeding rates increase competition between developing seedlings for light, water and nutrients, reduce plant size (Harris 1990) and potentially survival. The experiment reported here investigated the effect of plant density (created by differences in seeding rate) on plant morphology and survival. The hypothesis was that plants established from high seeding rates will be smaller and, therefore, less likely to survive the first summer; a period of substantial environmental stress (e.g., high temperatures, low soil moisture, insect attack)

Assessing the potential of autonomous submarine gliders for ecosystem monitoring across multiple trophic levels (plankton to cetaceans) and pollutants in shallow shelf seas

A combination of scientific, economic, technological and policy drivers is behind a recent upsurge in the use of marine autonomous systems (and accompanying miniaturized sensors) for environmental mapping and monitoring. Increased spatial–temporal resolution and coverage of data, at reduced cost, is particularly vital for effective spatial management of highly dynamic and heterogeneous shelf environments. This proof-of-concept study involves integration of a novel combination of sensors onto buoyancy-driven submarine gliders, in order to assess their suitability for ecosystem monitoring in shelf waters at a variety of trophic levels. Two shallow-water Slocum gliders were equipped with CTD and fluorometer to measure physical properties and chlorophyll, respectively. One glider was also equipped with a single-frequency echosounder to collect information on zooplankton and fish distribution. The other glider carried a Passive Acoustic Monitoring system to detect and record cetacean vocalizations, and a passive sampler to detect chemical contaminants in the water column. The two gliders were deployed together off southwest UK in autumn 2013, and targeted a known tidal-mixing front west of the Isles of Scilly. The gliders’ mission took about 40 days, with each glider travelling distances of >1000 km and undertaking >2500 dives to depths of up to 100 m. Controlling glider flight and alignment of the two glider trajectories proved to be particularly challenging due to strong tidal flows. However, the gliders continued to collect data in poor weather when an accompanying research vessel was unable to operate. In addition, all glider sensors generated useful data, with particularly interesting initial results relating to subsurface chlorophyll maxima and numerous fish/cetacean detections within the water column. The broader implications of this study for marine ecosystem monitoring with submarine gliders are discussed

Submillimeter Array Observation of the Proto-Planetary Nebula CRL 618 in the CO J=6-5 Line

We report on the results of a Submillimeter Array interferometric observation of the proto-planetary nebula CRL 618 in the 12CO J=6-5 line. With the new capability of SMA enabling us to use two receivers at a time, we also observed simultaneously in the 12CO J=2-1 and 13CO J=2-1 lines. The 12CO J=6-5 and 13CO J=2-1 lines were first interferometrically observed toward CRL 618. The flux of the high velocity component of the 12CO J=6-5 line is almost fully recovered, while roughly 80% of the flux of the low velocity component is resolved out. The low recovery rate suggests that the emission region of the low velocity component of the 12CO J=6-5 line is largely extended. Continuum emission is detected both at 230 and 690 GHz. The flux of the 690 GHz continuum emission seems to be partially resolved out, suggesting dust emission partly contaminates the 690 GHz continuum flux. The cavity structure, which has been confirmed in a previous observation in the 12CO J=2-1 line, is not clearly detected in the 12CO J=6-5 line, and only the south wall of the cavity is detected. This result suggests that the physical condition of the molecular envelope of CRL 618 is not exactly axial symmetric.Comment: 24 pages, 9 figures, 1 table, accepted for publication in AJ. Full resolution version available at http://www.asiaa.sinica.edu.tw/~junichi/paper

Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions

Patients with schizophrenia are known to have impairments in sensory processing. In order to understand the specific temporal perception deficits of schizophrenia, we investigated and determined to what extent impairments in temporal integration can be dissociated from attention deployment using Attentional Blink (AB). Our findings showed that there was no evident deficit in the deployment of attention in patients with schizophrenia. However, patients showed an increased temporal integration deficit within a hundred-millisecond timescale. The degree of such integration dysfunction was correlated with the clinical manifestations of schizophrenia. There was no difference between individuals with/without schizotypal personality disorder in temporal integration. Differently from previous studies using the AB, we did not find a significant impairment in deployment of attention in schizophrenia. Instead, we used both theoretical and empirical approaches to show that previous findings (using the suppression ratio to correct for the baseline difference) produced a systematic exaggeration of the attention deficits. Instead, we modulated the perceptual difficulty of the task to bring the baseline levels of target detection between the groups into closer alignment. We found that the integration dysfunction rather than deployment of attention is clinically relevant, and thus should be an additional focus of research in schizophrenia